Alzheimer's blood test

Alzheimer’s blood test catches 90% of early dementia cases, study finds

To be honest, not sure if I want to know as there is limited medication right now.

Other than making sure your affairs are in order, which is recommended anyway, not sure what benefit this has right now?

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But there’s no treatment, it would just give me anxiety if I knew I was predestined to get this horrible condition

European Medicines Agency (EMA) has rejected a licence for an Alzheimer’s treatment which slows cognitive decline.

The EMA said the benefits of lecanemab did not counterbalance the risk of serious side effects, especially bleeding and swelling in the brain.

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The few medicaments for AD are incredibly expensive and have not thrilled with their results. In the early 90s, I started working with scientists trying to develop treatments. Things have not progressed very far since then. >30 years, and almost no progress.

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Funny, I’ve watched some material recently about AD. The scientists highlighted that the bad protein is removed from the brain during a deep sleep. My takeaway is to take sleep hygiene seriously, best medicine I’ve ever herd off :grin:

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The lack of progress is not surprising as they all concentrate on removing the typical brain plaques although they may be symptoms not a cause.

To be fair there is little else to focus on.

Another small study which may prove promising.

Info coming thick and fast atm.

A new study " SGLT-2 inhibitors might prevent dementia"

SGLT2 inhibitors are a class of prescription medicines that are FDA-approved for use with diet and exercise to lower blood sugar in adults with type 2 diabetes

  • This large population based cohort study among people with type 2 diabetes aged 40-69 years found a 35% lower risk of dementia associated with use of SGLT-2 inhibitors compared with DPP-4 inhibitors

  • This finding persisted regardless of dementia type and across subgroups of diverse population characteristics such as age, sex, concomitant use of metformin, and baseline cardiovascular risk.

  • Please note that Type 2 diabetes substantially predisposes people to Alzheimer’s disease and vascular dementia through multiple pathways so giving this treatment to people who do not have Type 2 may not reduce the risk of dementia

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:smiley:
Don’t worry, statistically speaking, the chances of dying of heart condition, or of any type of cancer, are much higher than developing dementia

More, seriously, I would recommend the “Meditations” (Marcus Aurelius) – one of the early stoics, who rightfully said that “while preparing for what might happen is wise, becoming consumed by fear of it is a pointless suffering of imagination, not reality”.
And also, less stress, more social contact, physical moderate activity, and a lot of ‘slow food’ for the brain (books, crosswords, chess, singing, card games, classical music, etc) could help. @Tom1234 , I said ‘could’ :wink:

And rightfully so… it works only in early stages of dementia, the improvement is very very marginal (6 months vs placebo), and in up to 10% of the patients there is not just ‘brain swelling’ (which is bad enough)', but also brain bleeding (stroke) as TAE (Therapy Adverse Effect) . Imagine the pain of seeing your loved one not just now ‘forgetful’, but also bed-ridden and incapacitated – not to mention the costs.

I understand and agree that, (like for ALS or other neuronal conditions), if there is no cure, all and everything should be tried. But… which are teh limits?

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Is it only me or is this article absolutely nondescript and bare of any substantial information?
I still have no idea why cherries and why cherry powder is better. So I perked up at the last sentence:
“The study was carried out in partnership with Rent A Cherry Tree - a cherry tree business in Northiam, East Sussex.”
Now that is a cool idea, I would rent fruit trees for a season.