GLP-1: Mounjaro (Tirzepatide), Ozempic/Wegovy (Semaglutide) and diabetes?

My resting heart rate had been 44 for about 40 years, then I started seeing readings as low as 33, a year later I found my Mitral valve was prolapsed & had surgery to repair the valve. After surgery they sped up my heart to 80, a year on resting heart rate is 52, but seems to be dropping. During my sleep at the weekend it went as low as 38.

I have a resting bpm of 70 ro 75, durung exercise I can get to 90 but it dfops back to 70 very quickly.

Bradycardia runs in my family, so I’m not concerned it is any defect.

Heart defects, including valve issues, can have a genetic component.

I assume this has been dismissed at some point?

Wait, your pulse raises ONLY to 90 during exercise? Do Brits also measure the blood pressure in inches of Hg and the pulse in new type of time measurements? I thought i was pretty sporty, and my heart reaches 135 bpm during exercise…(jogging at 10.5 km/h)

Washington’s Dream - SNL

No idea, but after a session bp is between 90/60 to 110/70.



Note the gym where everybody suddenly decided that the stationary bikes around the corner look good.

2 Likes

You’re only missing the viking hat.

1 Like

I think it depends on the exercise.

Mine probably doesn’t go above 90 doing some body-weight type exercises but can go up to 175 bpm cycling up a steep prolonged hill.

Running (let’s not call it jogging, you are doing yourself a dis-service calling it that), raises the heart rate pretty quickly, even if you are pretty fit.

All the above is just observations I have made.

2 Likes

That looks like a lot of fun. You inspired me to try something like it. The closest thing I had to hand was a large heavy bike lock and I tried swinging that around and it was surprisingly enjoyable and I could feel muscles were exercised even if it was light.

I’ll have to buy some heavier kettlebells and try again. Those maces look great, but I don’t think I have room to swing those around!

That is why i stationed them at the gym, no room inside and not confident enough to use them in public.
The maces come in 5, 7, 10 and 15 kg and I got them via Kleinanzeigem for 120€’s.

I could imagine they can be considered 'weapons of mass destruction if left on the wrong hands…(mine for example). I would probably accumulate injuries, court cases, and years of bad luck if I try to swing that above my head…

@slammer goodness gracious! you could demolish a full house single-handed with that sh*t!

p.s. disclaimer: I read bpm (beats per minute) instead of bp (blood pressure). That’s why I was going bananas about my bad health! :smiley: thanks @Tom1234 .

I advise dropping carbs entirely for a few months or as much as possible. Also drop fruits with the exception of 2-3 berries per meal. There’s plenty of high protein zero fat chocolate mousse or flans that can help with sweet cravings.
Reading ingredients is s game changer.

Food and exercise are actually not super tough. Work stress thats a difficult one because its not about your choices, there are entire orgs are tasked to play with your stress level to squeeze productivity…

1 Like

You may want to get blood lancers and blood glucose monitors. They should be more precise.

1 Like

Well, first three weeks have been quite good. I’ve gone from 97 to 93kg in the first 3 weeks, having cut out 95% of the sweets I use to consume. The wegovy does help curb the cravings, and if I do have a big meal, I tend to regret it later.
Spoke with the doctor, will go to 0.5mg but I think that is where I’d like to maintain if possible. Goal is 80kg, any under that is a bonus.

2 Likes

One thing with semiglutide - I read this somewhere and can’t remember where, it might have been Eric Topol, who is an MD, and he looks at a lot of modern health stuff.

Anyway, he was saying that semiglutide (ozempic, wegovy) do a much better job at curbing the desire to eat greasy stuff and not as good at curbing sweets. So if you’re taking these meds, it’s good to be mindful of that.

I don’t know if the same holds true for tirzepatide, monjuaro.

1 Like

Yes you are right, I still have the occasional craving for something sweet, but these are becoming less and less since really cutting down on sweets in general. The greasy stuff is definitely becoming less attractive.

1 Like

All that you have written here is all wrong on so many levels and is typical of the nonsense spread on Youtube and Social media.

A handful of blueberries contains only about 50 calories but provides vitamins, fibre, anti-oxidants and of course, sweetness.

One of the biggest problems with peoples’ diets these days is they don’t contain enough fibre (which can lead to many, many health problems).
You cannot get fibre in your diet without carbohydrates as fibre is a carbohydrate.

Eat oats - slow release carbs and full of fibre.

And eat fruit and vegetables!

There’s mounting evidence that artificial sweeteners trigger responses which make people fat in the same way as sugar does.

AI overview:

Studies suggest that fake sugar may lead to weight gain, despite being low-calorie. Potential mechanisms include altering gut microbiota, which affects food processing and glucose metabolism, and promoting metabolic dysfunction or an unhealthy gut microbiome. Some research also shows a potential link to increased cravings and impaired blood sugar control. The World Health Organization (WHO) has advised against using artificial sweeteners for long-term weight control.

If they did, they wouldn’t be having your recommendation of Ultra-processed brown gunk containing a whole page of dubious chemicals masquerading as ingredients.

Probably better, when losing or maintaining weight, to basically avoid anything with “ingredients” unless it’s something like soy sauce.

1 Like

What use would a CGM be, beyond satisfying the cat’s curiosity?
You already know what you need to do, and where the biggest traps lie.

Kee phrase. For a few months. Not forever. My 2 cents, drastic measures (drop pasta, pizza, potatoes, bread and cakes altogether) are easier than trying to adjust slowly. If you cannot stick to it, its not going to work longterm. For some people, it works.

Ymmv.

You did say no carbs. Which is unhealthy. Complex carbs should be eaten as part of any diet.
And then you recommended some UPF junk as a replacement.

The ones you listed above are unhealthy if someone has type 2 or pre-diabetes but putting that aside, apart from the cake, all the other ones you listed don’t actually get eaten alone.
No-one is going to chomp through plates of plain boiled pasta, plain bread or pizza bases in sufficient quantities to make them fat.
In the same way as people who crave sugar don’t spoon it into their mouths.
They all have other things added and it’s the total calories together which people are consuming in too large quantities.

White rice is seen as an evil by many but you don’t get many obese Japanese and they eat a lot of it in various forms.
The key take-away from this, and from everything related is quantity. The Japanese have very small bowls of rice.

If you want to lose weight, you need a calorie deficit and in the end, although some things are healthier than others, it’s still calories in which is going to make a difference - up to a point.

I say that as new research suggests that UPF food (which you recommended) appears to cause more weight gain than a non-UPF diet:

People gain more weight on an ultra-processed diet than when eating a minimally processed diet, even when they eat the same number of calories, new research has found.

The study of 43 men aged aged 20 to 35 pitted nutritionally similar unprocessed and ultra-processed diets against each other and found men gained around one kilogram more of fat mass while on the ultra-processed diet compared to the unprocessed diet.

This could partly explain the fairly recent rise in obesity.

https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00360-2