GLP-1: Mounjaro (Tirzepatide), Ozempic/Wegovy (Semaglutide) and diabetes?

i am not laughing… I only added 3 hard boiled eggs to your breakfast :wink: pure protein and vitamin! :slight_smile:

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Ah! Sorry no eggs.

Will do. Surprised you are happy with a creatine supplement. As I understand it, the supplement is likely to have originated in the waste bucket from a meat or fish processing plant and then been subjected to some heavy chemistry. Sounds like ultra processing. My salmon is hopefully antibiotic free, lightly smoked and then freshly cooled or frozen.

Not “likely” at all. It’s a synthetic product. The “chemistry” involved is no more complex or dangerous than any other synthetic medication or supplements.

Yes, it is 100% synthetic. And pretty straightforward to make. Purified by selective crystallization. 100% pure, 13C and 1H NMR – 100% proof. Cool stuff.
Easy. Fast. Like the LSD that I cooked at the lab during my PhD :wink: - but that’s another story.

This is creatine; N-amidino sarcosine. Not so difficult to synthetize in the lab. For info, the molecule is on CTII/III for Huntington disease, Duchenne’s, ALS, MS, Parkinson and some other neuro-muscular disorders.

Creapure vs Creatine: The Key Differences to Know – Momentous

Would I rather NOT take it? For sure. I tried the root of the Salmon / rich omega3 protein, natural remedies, but I kept on losing muscle, piling fat and losing concentration. Except with Ginseng. It worked (on the concentration), but on the wrong target. Yes, I was concentrated… and focus…but not on excel… I was ‘attacking’ :wink: my hubby 3 times per day :open_mouth: . :smiley: :smiley: :smiley:

That’s science! :rofl:

Goes to order a bulk pack of ginseng for the missus

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So I clicked, at random, on one of the studies used in the meta-analysis where four subgroups were used ( (control-creatine; control-placebo; trained-creatine; trained-placebo) ) and read:

We conclude that oral creatine supplementation does not provide additional benefits for body composition, maximal dynamical strength, and dynamical and isometric endurances of healthy elderly subjects, whether or not it is associated with an effective strength training.

And another with elderly women:

Changes in fat mass, bone mass and serum bone markers did not significantly differ between the groups

I’ve read similar elsewhere. Even your meta-analysis sums it up saying there is no statistical difference.
So it looks like it increases endurance - people can, for example, do one more rep of an exercise.

For something that people are going mad about, it doesn’t seem to be that effective, does it?

What really makes a difference in muscle hypertrophy is carrying out those repetitions to near, or actual failure (rather than just doing ten, or fifteen light-hearted rep).
That must be difficult to measure.

Which could be down to the protein powders alone.

I was told by a personal trainer that it is pretty difficult to exercise until failure as people naturally keep a few reps in ‘reserve’. As a trainer, she really had to push them until they got to the point of failure.

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….do explain!
Starting to think twice before I ever try that honey of yours, or is „honey“ a code Word that I dont know.

Mad Honey!

Thanks for the correction. I had got mixed up between general protein supplements which are usually highly processed plant or animal matter and single amino acid derived products which are often made synthetically or possibly using fermentation. It is still bizarre that people who are into low processed natural products then take supplements that may be the very opposite.

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I had one last night before I went to the cinema, I had a craving for one after reading that comment :laughing:

A crusty halbweiss Doppelbürli roll with tartare sauce, 3 fish fingers, salad leaves and a thinly sliced gherkin. Seriously yummy!

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I have the distinct feeling that Izzy the busy bee has more going on than we know.
You know: “Breaking bad, the honey files”

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Oh, I don’t know. Anyone that grew up in the late 60s, early 70s likely has dropped a tab or three. :rabbit_face:

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More like “amazing rainbow”, nothing bad about it.

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RoFL. that was on my wild days. Who didn’t have them???

oooohhhh I laughed so much when I saw the 1st episode of ‘breaking bad’. (for some strange reason, all of my friends told me ‘you have to watch it!!’) — It was soooo badly setup! I didn’t watch any other episode, not worth.

Yep, I have my hands in many (honey)pots’ :smiley: but of course, all legal!

p.s. the same friends told me I should watch ‘Up in the air’, as that was my life on the 2000s… :frowning:

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Yes, watch it!

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Mine too, from the nineties to 2013, thats when things went to shit career wise.
I had and still have a large samsonite suitcase nicknamed. “The Herniator” by my colleagues, but I loved it.
Havnt seen “up in the air” but I will look for it.

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Not about diet as such but this podcast makes so much sense - straight-talking, no-nonsense stuff so may not appeal to those who prefer getting their info from influencers or supplement-funded sources.

Key takes -

Mxany of the scientific studies which show this and that are funded by the companies suppling the products. Meta-analysis shows no effect.

Walking is great doing that sort of thing everyday will be better for long-term health then a few quick sessions in a gym.

Fibre, carbs, fat… and protein are all essential for good health but we probably don’t eat enough fibre and think we don’t eat enough protein.

Collagen - the protein found in those UPF products like High Protein Coffee is no good for building muscle, nor smoothing wrinkles but collagen may show a modest improvement in mobility for those with joint issues.