GLP-1: Mounjaro (Tirzepatide), Ozempic/Wegovy (Semaglutide) and diabetes?

A bit over 5 weeks into Wegovy (and after 2nd dose at 0.5mg), I’ve gone from 97.5kg to 90.5. kg.Here is the summary from my Garmin Index S2. Concerning is that around 25% of the weight loss so far appears to be muscle, despite maintaining quite good excercise. Just gonna have to up the strength training, at least the weather rigt now is good for it.

Seems to have also impacted my FTP, with raw power dropping. W/kg remaining constant with the weight loss.

1 Like

Muscle is “expensive” for the body to maintain, especially as it senses the drop in calories. Strength training will help, though.

Could that be because you have reduced carbohydrate intake? That would certainly do it - especially over an hour if taken literally.

Possible, can’t say I was tracking carb intake before, during and after these activities.

But you are obviously eating less and you must have a rough idea of what you are eating day to day.

I’m assuming that this isn’t a one-off measurement of ftp and if so, it’s probably not even worth mentioning.

I would suggest getting an expert (doctors) opinion on those smart watch readings and whether or not you are over-interpreting them. You measure your weight fairly directly. The other measurements are interpretations of impedance data.

Just over a year ago thr doc sent me to a specialist who wanted to flog some tried and tested powder supplement.
When I asked I was told it is a patented suppliment and a secret. It costs only 5000€ for a six month supply.
I was not polite when I left, even less polite to my doctor who then apologized.

The next was a surgeon who looked at me thinking his vacation was secure, he told me I needed my stomach removed, without even a glance at my food plan and the fact that I could tear him limb from limb should I be so inclined.
Why is losing weight so riddled with grifters and so-called experts riding the gravy train?
I dont want to lose on my legs, ass, back, shoulder and arms. I just want to get rid of this medicine ball.
How many times have I heard that I need to eat less and exercise more? My general response is to tell them that we can go to a gym and see who craps out first.
“…only trying to help!” Is the sanctimonious reply.

2 Likes

Evidently because people keep going to them… :wink:

The weight, body fat%, muscle %, etc come from a smart scale. Yes, the individual measurements may not be accurate, but the trends over time have value.

The FTP / power measurements come from my left/right in-crank power meter fitted to my road bike. This is very accurate, although I have noticed lately I have a greater left/right imbalance as I did earlier this year.

It’s because losing weight can be very difficult and people are desperate.

And when people are desperate, the scam artists and con-men/women appear.

2 Likes

I didn’t see the chart when I replied last. Crank meters, as you say, are incredibly accurate.

If I’m ever underperforming on a bike, it’s down to lack of carbs above all else.

I was trying to be helpful. Even the high tech muscle and fat determinations are difficult to calibrate. I would like it if there were error bars on these measurements - helps estimate how reliable a trend actually is. My limited knowledge would wonder if a power loss is related to lower calorie intake/blood sugar than actual loss of muscle, especially if exercise and protein intake are not being reduced.

1 Like

Yes, I appreciate your effort to help, I just wanted to clarify that the info was not (just) from a watch, but also from a scale. And yes, they are hard to calibrate, especially as fit vs sendentary can also influence readings greatly. But I think on the whole, if you use “exactly” the same device as a point of reference, the trend for the measurement can have integrity. For example, the body fat% is declining which is all I need to know for that, not if it is 31% or 30%.

And yes, the lower “nutrition” intake maybe having an effect on performance, not to mention the possible side effect of the medication itself.

The other reason you’ll end up losing more lean muscle mass over time is simply because you’re
losing all that weight which your body needs muscles to carry around.

OK, you’ve only lost 10Kg but imagine carrying around two 5Kg dumbells the whole time and compare that to the puny minute or so that people carry that weight when their muscles are actually under load in the gym doing reps.

So, you could look at it in a positive way!

1 Like

Currently watching this video:

it reminded me of this…
Enhancement Drug - SNL

:smiley: :smiley: :smiley: :smiley:
I read @litespeed

…and it reminded me on an article that I read some time ago. I found the abstract. It reads…
“… Body size is the most obvious characteristic of living things. It is also arguably the most important because it constrains the rate of all biological reactions within organisms and influences how they interact with their abiotic and biotic environment. The essential activities of survival, reproduction, and growth are governed by the rate at which organisms acquire, process, and transform energy, which is largely determined by body size and temperature. Over evolutionary time, the complex interactions between metabolism, body size, and environmental conditions have led to a number of well-documented ecogeographic gradients. These include the island rule (dwarfing of large animals on isolated islands, gigantism of small ones), Bergmann’s rule (a cline in body size within species or genera with larger-bodied populations or species occupying colder climates), and Cope’s rule (an evolutionary increase in body size of lineages over geologic time). The first two rules are clearly related to energetic tradeoffs in some fashion, although causal mechanisms remain unclear. The status of the last is uncertain.”

so, you are NOT of the wrong body shape, @Slammer , you are just in the wrong country! :sparkles:

1 Like

Fascinating video. Bit long, I am still working my through it.
Wow, a doctor with an encyclopaedic knowledge of biochemistry.
Not sure why he is so hard on aerobic exercise. In the gym fair enough, do resistance training; but getting out in the fresh air walking, jogging, cycling etc etc is so good for you on many levels.
He also advises against vegetable seed oils because of omega 6 levels -very debatable.

2 Likes

Patented and a secret? That’s not how patents work on average. All patents required a good description of the product or process to protest. Patents which are regarded as sensitive in the context of defense, nuclear, and that kind of stuff are kept secret for a while at the request national governments. Thanks for fighting quackery. One damned fraudster at a time.

I’d laughed a bit with the SNL video shared by Izzy_the_busy_bee, but it’s also a sad truth. Amphetamines are so easy and so cheap to produce that selling “natural supplements” fortified with a low dose of amphetamines it’s an interesting business case.

It’s a been a challenge to keep my dad away from such frauds. He wants to believe that there’s a plant which is better than all medicines produced by humans…and there’s plenty of people out there willing to cater that need to believe.

End of week 7, around 6kg lost (ca. 0.8kg per week). I have noticed a bit more side-effects, including slight headaches, stomach aches and reflux. But overall, proceeding well. I have agreed with the doctor to continue another month on 0.5mg instead of upping to 1.0, as I am seeing results. Also I am concerned about a higher dose affecting sport performance. My cycling wattage has dropped since I started, although W/kg has increased slightly.. I am also feeling much lighter when I run, needing to walk less on the uphills.

Best of all, my clothes are feeling much looser. :slight_smile: I am also not in a hurry, as would rather loose the weight slowly than fast for greater sustainability.

4 Likes

The updates are pretty cool, seeing how it’s going in real time!

2 Likes