GLP-1: Mounjaro (Tirzepatide), Ozempic/Wegovy (Semaglutide) and diabetes?

Interesting article on targeting the right weight-loss drug:

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:zany_face: They have six packs - but they're still jumping on and off weight-loss jabs

How can someone 1.69m tall weight 76 kg while being fit? This is not only muscular, but bulged muscles level of training.

But “nothing worked” for the Brazilian lawyer who weighed 76kg (11st 13lb) and is 1.69m tall (5ft 6in).

Gabriela’s BMI was 26.6 when she started taking the jabs. She had no weight-related conditions and was a muscular woman who regularly did high-intensity exercise.

Playing with the body at that level is serious stuff. Social media is regularly toxic, this recent video is surprisingly honest and intellectually curious. A bit of pop-science by linking body fat measurements to real people. They still sell a product and a lifestyle, but
well, they need to earn a living somehow.

I appreciate how the video was structured, asking people about how they feel, how they sleep, their level of energy, obsession with food. The people with 50% body fat tell about being tired and not sleeping well. People with 20-30% boy fat are happy, look great, have energy in their daily lives. As body fat goes low into pro-body builder territory(less than 15%), troubles to sleep, craving for food the whole day, feeling dizzy for minor physical effort while having a body that looks athletic. Being this lean must be your job because they have troubles to concentrate, an intellectual job is out of the question. I’m not dissing here, it’s just that rational thinking is not a priority for the body, the the lack of fat puts people into survival mode.

A huge footnote for the video is that they’re all young. Save for the 47 YO woman who won the genetic lottery haha. The problems they talk about plus AGE make everything more challenging.

If I were the lawyer and had the muscles, I’d just count (and celebrate) my blessings. This has been a challenging year and I do exercise (walk, run, ride the bike) only to sleep well. No objective beyond being able to sleep within 30 mins after lying in bed.

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Unless they are specifically selling an exercise programme or book, I’ve found that everyone who is selling something had data which is dubious.

We just don’t need those supplements or fads and if we need something special, it’s probably because our doctors have suggested/prescribed it.

The world is currently in the “We don’t get enough protein !!!” era.

There are plenty of people on here taken in by the social media / newspaper trends.
The supermarkets are full of high-protein coffee, cheese (really?) and so on.

Luckily, commonsense and science has started to prevail and ‘new research’ has shown that people eat too much protein, it’s bad for their kidneys and is actually making them fat.
The body needs carbohydrates to function too.

You can have body fat below 15%, a six-pack and have lots of energy but you need carbohydrates to give you the energy to lift those weights or do for that run.
It’s not particularly healthy to be like that though and you are more likely to suffer from the cold - especially in an emergency.

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I have 100% salaried work, my own business endeavours, and spend a lot of time arguing online
all I want is to be relatively light, flexible and sleep well. Once I got the body fat measured I had around 20%, currently a bit more :slight_smile:

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The BBC followed a group of people who were on these jabs and they mostly did really well. Importantly, they were able to limit or come off other meds for obesity-related medical conditions.

I finally understood what drives obesity in some of these cases. One of the women was saying that the injections prevent this “food-noise” that is constantly playing in her head. Once that is shut off, then cutting back on food doesn’t seem to be so difficult. Stop the injections and the food-noise starts up again.

I wonder if there could also be some cognitive behaviour exercises that would do this via therapy?

My former school friend in the UK has three kids and one of them is really quite overweight, whereas the other two are slim and athletic. The larger son is constantly badgering for food, and it’s a real issue for my friend because, for the first two kids, she didn’t need to worry about them constantly raiding the fridge.

The BBC article states:

People who come off slimming jabs regain weight four times faster than dieters

Possibly as dieters are using at least a bit of will-power and mental planning to enable them to lose the weight, and probably having to change what they eat compared with those having the jabs where they don’t need will power and theoretically don’t need to change their diet but just eat less of whatever made them fat in the first place.
When they come of the jabs, they eat more of what they ate before.

Probably better just to take the jabs for life and offset the cost on what you are not spending on food.

I read the BBC article this morning. What I wonder though is has it actually been established what these jabs are doing to people in the long term? Hospitals in the UK have seen a big increase in women with gall bladder issues who’ve been on them and believe me from experience you don’t want to go there. I spent 10 days in hospital shortly after New Year in 2014 and I have never felt pain like it (had to be dosed up with morphine as I was hysterical most days). They had to take my gall bladder out as I was very close to developing pancreatitis. I lost a stone in 10 days as I was living on boiled sweets, black tea and water. I’ve had intermittent gut issues ever since as I now suffer from bouts of bile acid malabsorption and have had to completely eliminate certain foods.

I also remember when Orlistat was approved in Britain and overweight people being prescribed that, downside was it caused explosive diarrhea that came on suddenly without warning. The BBC did a documentary on it and people were saying they’d suddenly been caught short when out and had soiled themselves in public.

Then there’s slimming clubs, they rely on people regaining all the weight loss as that’s what they make money from, people rejoining. I made the mistake 35 years of joining a WW group to keep my sister company, I was not much more than 8 stones at the time but told I needed to lose at least 12lbs. The group leader had big blown up photos of herself taken when she was absolutely huge and used to shout things like “little pickers wear bigger knickers” at anyone who hadn’t lost weight that week. There was one really big girl who used to strip down to her underwear before getting weighed and it was just an exercise in fat shaming if you ask me.

Interesting. but hardly surprising. Ozempic is a hormone agonist, there are almost guaranteed to be side effects that will become more apparent as more people take them.
I am on a low dose of Beta blocker. When they first came out they were heavily over prescribed as they really do have wonderful effects. Nowadays the dosage has been reduced and they are no longer seen as a cure-all.
Time will tell where the weight loss jabs go.

I wonder how many anti-vaxxers are on Wegovy?

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I suppose most were healthy with good immune systems rather than obese

I very much doubt that.

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Why? I thought the bed wetters tended to consider themselves vulnerable.

Ironically, preventable diseases such as measles, tetanus, meningitis, and polio all can cause neurological damage which causes incontinence. So there’s more chance you’ll wet the bed if you’re unvaccinated. Funny how things work out, innit?

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Humans are weird.

Side effects of weight loss medicine: nausea, headache, dizziness, fatigue
divorce? The discussion about self-esteem and self-control are quite interesting.

The partner path injection – weight loss agents such as Ozempic can ruin relationships

If a partner with medical support quickly takes a lot off, the risk is twice as high that a couple will separate in the next few years. This was found by a Swedish study by the University of Gothenburg in 2018. 12 500 overweight patients were examined, who had their stomach reduced surgically.

A study by the University of Pittsburgh confirms the finding: The rapid weight loss of a partner more than twice as likely to lead to separation in the following years compared to the general population.

The researchers predict even more divorces in the future because of the popularity of the new weight loss agents. Since 15 million Americans are currently using the funds permanently and the numbers are rising in many countries, including Switzerland, they are likely to be right.

At the same time, the experts are trying to reassure: This would above all end “unhealthy” relationships. The increased self-esteem encourages sufferers to break away from toxic connections.

Kurzgesagt video on GLP-1s. Given the benefits, I imagine it would be cost effictive to give it free to the population to reduce healthcare costs.

To be honest, I’d rather they spend the money on addressing the problems which are causing this problem and do something about Nestle and others who are creating the sort of addictive junk ‘food’ which is creating this problem.

In a way, ready availability of these fat-jabs does hurt Nestlé et all. They suppress appetite meaning people buy less junk food.