GLP-1: Mounjaro (Tirzepatide), Ozempic/Wegovy (Semaglutide) and diabetes?

The equivalent today is car crashes. Higher body weight & BMI are correlated to higher mortality in car crashes. Maybe co-morbidity (already sick), maybe increased severity of injury (force = mass*acceleration). The same crash for a lighter body means lower forces in the body.

Or crash dummies being 1.78m and 77kg. All the tests (and thus cars) are made for these “bodies”.

But realistically, this isn’t sustainable in any non-prison circumstance. That’s starvation and as you know, the body will lose a lot of water weight at first, then weight loss and metabolism will slow way down, to the point where you’d be lethargic and weak and barely losing any weight. This is an interesting quasi case study.

The same as dropping a mouse down a well, it will bounce one and run away, now drop a horse down a well…

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That is what I found, the first three weeks was low hanging friut. After that the loss became slower.
The trick is to feed yourself so that you dont become weak and lethergic.
Typical daily intake could be a slice of bread with a wheel ot two of sausage, friut and a cuppa, 250 to 300g, they during the day water or tea aabd for tea a chicken leg and a salad.
Perhaps a slice of bread with something on it for lunch.
All in all a kilogram

You can’t weigh different things, weighing would only be meaningful if you weighed specific amounts to count calories, ie 50g of rice, 150g of chicken breast etc.

My understanding of the theory I haven’t managed to put into practice re weight loss is that sustainable weight loss needs to be a lot slower than most people realise. 0.5kg/week, with 1kg/week losses being in the beginning when the weight loss is rapid. This is through mild calory restriction, not barely staying awake!

I’d guess that the only reason the GLP1s and surgery work is that they make you physically/mentally unable to eat much. This is also why the weight returns for many on GLP1s upon stopping the drug, and not after surgery (as the stomach is so radically altered).

You can make it more efficient by building up and maintaining muscle mass. Muscle is more energy hungry than other tissue.

Theoretically yes, but I doubt anybody would weigh each and every ingredient. That is why I generalize.

Certainly, but that comes with its own set of challenges. Personally I am quite happy with the muscle mass I’ve put on the last 4 years where I am lifting hard and consistently, weight has remained stable but body shape (and I imagine composition, but didn’t get measured) has changed. I just want to lose the belly and make my motorcycle faster.

I certainly don’t bother, but I am sure some people do. Still, in my opinion you can’t generalise because you’re including different things. A kilo of butter is radically different in calories than a kilo of lettuce. Again, I feel the reason these interventions work when many others don’t is because they take all of this miserable shit (counting calories, low carb + high fat/protein, weighing grains of rice, 10 micromeals a day, women with anklewarmers on TV jumping around, munching on lettuce while doing 3000km/day on the treadmill staring at a wall) out of the equation and just force us fat fucks to be unable to eat :wink:

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I can’t imagine anyone being able to chomp through a kilo of lettuce in one sitting.

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2500 calories in a kilo of fish and chips!

You know that stress is probably just as much of a killer, right? Have that cream bun and stress ye no longer… :slight_smile:

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The following is a pretty important point regarding the research in this case:-

It is worth noting that the Danish participants in this study had all undergone body scans for health reasons. These scans are costly, so they are usually carried out for a good reason – when a health issue is suspected.

The researchers acknowledge that a possible reason for their findings is that participants could be losing weight due to an underlying illness, and so it could be the illness itself, rather than the associated weight loss that is increasing the risk of death.

Many health reasons for body scans but for people who are underweight and ill - it can quite often be a symptom of cancer, severe alcohol abuse, drug abuse, heart failure and so on.

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Spoke to a friend who also happens to be a surgeon performing gastric bypass in CH, confirmed that one is forced to totally alter their relationship with food, establishing a new normal takes around 2 years (!!!), and some things can essentially never be eaten again (heavily starchy things which expand in the stomach: rice, pasta, bread, potatoes). Confirmed it’s not “the easy way out”. If it was reversible I’d give it some more thought, however as it stands right now I’d struggle to consider it.

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i worked on the past on a product that is an ‘inflatable gastric balloon-on-a-pill’, that could be easily swallowed, and would stay inflated in the stomach for about 6 months, after which it would self-deflate and pass through the digestive tract.
On paper, a very good idea. On execution, also a very good idea. Yet, most of the people come back to the old habits, and regain the weight…

half of the problem is habits and environment. The other half, lack of will.

It’s not will-power, it’s won’t-power.

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Cost savings. It might be possible that GLP-1 drugs become “heavily incentivized” one day:

Globally, more than 500 million people have osteoarthritis. Knee arthritis is the most common form, affecting about 14 million people [in the US and more than 5 million in the UK. Many will require knee surgery. In the UK more than 120,000 knee replacements are carried out every year.

Being overweight or obese significantly increases the risk of developing knee arthritis, by placing greater load on the joints.

Previous studies have found that weight-loss drugs can help reduce the pain from knee osteoarthritis. Now researchers have found that taking medications such as Mounjaro and Wegovy, or those for type 2 diabetes such as Ozempic, could also help prevent the need for knee surgery.

I think a while back (in this thread?) we were talking about how simply losing weight bagged the need for knee surgery.

Novo Nordisk and Veru look into next-gen weight loss drugs which preserve muscle and lean body mass:

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