Ahoy captn’ obvious.
Indeed, the study infers that GLP-1 improves fertility rather than the resulting weight loss. There needs to be a comparitive study between “au naturale” weight loss fertility and that from GLPs
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Same question here: Is it the drug, or is it the weight loss that lowers risk of breast cancer? “All participants included in the study were females aged 45 to 80 years with a BMI of 25 or more.” (emphasis mine).
Obesity has a big influence on hormones (and vica versa), and many cancers have hormone receptors (most breast cancers do). So most likely it is also the weight loss directly, and GLP-1 indirectly.
This is why we’re seeing such an increase in reproductive cancers and early menarche in kids–fat kids mature earlier and have hormone-related problems later.
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And you need to study the people on these drugs with poor weight loss outcomes, to see the impact of the drugs alone. I think you might be looking at a largely diabetic population because even if you don’t lose a lot of weight, the drugs can still be beneficial for other outcomes.
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Apologies, I haven’t updated my experience in a while.
I am now approaching 11 months on Wegovy. I did the start of the year on 0.8mg dose then upped to 1mg after Easter. My weight has stabilised around 84-85kg, muscle mass as well, but my body fat has decreased from around 28% to 26%.
I am doing 2 hours of threshold gravel biking 3 times a week (ca. 37km with 850m of altitude climbing) and performance here is increasing (better times and power output). 5sec power almost back at 1Kw. My Strava segment times match riders 25 years younger, so not complaining.
So I am now beginning a ramp-down phase. I’ve been on 0.8mg the last month with no issues, and next month will go back to 0.5mg. I do hope to be off Wegovy by September.
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In the UK, the biggest winner long-term should be the NHS…less spending on obesity-related illnesses such as diabetes and heart disease.
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People will develop other diseases instead. And they’re likely to need more care due to higher age, so the total effect is probably net negative.
Disagree. Obesity is the main factor in many other diseases in so many ways.
Yes, true, but heart disease and cancer increase with age, so Roxi’s point has merit. We may just be fighting different diseases when we increase survival into 80s-90s.
Sure, but someone with an illness in their 80s or 90s has already paid a lifetime of taxes and health premiums. People with them in their 30s and 40s are a burden without much contribution.
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I wish I could find the article I read recently regarding why so many young people have cancers/illnesses of “older” people. It was about premature/accelerated ageing of the body, but here’s an interesting article:
Type 1 is NOT obesity-related.
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I am aware of that, apologies for not being more specific.
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A BMI of 25 is not considered obese. Or are we going the same pathway that cholesterol rates?
Anything over 24.9 is considered overweight.
Increasing age is the main driver for the ever increasing healthcare costs because the older you are the more of it you consume. If everybody died at a relatively young age, let’s say before 70, the cost situation would be far different.
Ill health is the major factor driving healthcare costs up.
Yes, a large factor here is of course that people are living longer but younger people are now getting ill in way which only used to affect older people.
One could argue, that in the long term, these young people, as they age, are going to cost the healthcare system much more than current crop of old people.