Ahoy captn’ obvious.
Indeed, the study infers that GLP-1 improves fertility rather than the resulting weight loss. There needs to be a comparitive study between “au naturale” weight loss fertility and that from GLPs
Same question here: Is it the drug, or is it the weight loss that lowers risk of breast cancer? “All participants included in the study were females aged 45 to 80 years with a BMI of 25 or more.” (emphasis mine).
Obesity has a big influence on hormones (and vica versa), and many cancers have hormone receptors (most breast cancers do). So most likely it is also the weight loss directly, and GLP-1 indirectly.
This is why we’re seeing such an increase in reproductive cancers and early menarche in kids–fat kids mature earlier and have hormone-related problems later.
And you need to study the people on these drugs with poor weight loss outcomes, to see the impact of the drugs alone. I think you might be looking at a largely diabetic population because even if you don’t lose a lot of weight, the drugs can still be beneficial for other outcomes.